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検索結果 11 件
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Impacts of Age and Gender on Brain Edema in a Mouse Water Intoxication Model
| JaLCDOI | 10.18926/AMO/66914 |
|---|---|
| フルテキストURL | 78_2_115.pdf |
| 著者 | Nakamura-Maruyama, Emi| Irie, Keiichiro| Narita, Kazuhiko| Himi, Naoyuki| Miyamoto, Osamu| Nakamura, Takehiro| |
| 抄録 | Brain edema causes abnormal fluid retention and can be fatal in severe cases. Although it develops in various diseases, most treatments for brain edema are classical. We analyzed the impacts of age and gender on the characteristics of a water intoxication model that induces pure brain edema in mice and examined the model’s usefulness for research regarding new treatments for brain edema. C57BL/6J mice received an intraperitoneal administration of 10% body weight distilled water, and we calculated the brain water content by measuring the brain-tissue weight immediately after dissection and after drying. We analyzed 8-OHdG and caspase-3 values to investigate the brain damage. We also applied this model in aquaporin 4 knockout (AQP4−) mice and compared these mice with wild-type mice. The changes in water content differed by age and gender, and the 8-OHdG and caspase-3 values differed by age. Suppression of brain edema by AQP4− was also confirmed. These results clarified the differences in the onset of brain edema by age and gender, highlighting the importance of considering the age and gender of model animals. Similar studies using genetically modified mice are also possible. Our findings indicate that this water intoxication model is effective for explorations of new brain edema treatments. |
| キーワード | brain edema water intoxication model age gender AQP4 |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2024-04 |
| 巻 | 78巻 |
| 号 | 2号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 115 |
| 終了ページ | 122 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2024 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 38688829 |
Association between Radon Hot Spring Bathing and Health Conditions: A Cross-Sectional Study in Misasa, Japan
| JaLCDOI | 10.18926/AMO/65749 |
|---|---|
| フルテキストURL | 77_4_387.pdf |
| 著者 | Kataoka, Takahiro| Habu, Hiroshi| Tanaka, Ayumi| Naoe, Shota| Murakami, Kaito| Fujimoto, Yuki| Yukimine, Ryohei| Takao, Soshi| Mitsunobu, Fumihiro| Yorifuji, Takashi| Yamaoka, Kiyonori| |
| 抄録 | No epidemiological studies have examined the health effects of daily bathing in radon hot springs. In this cross-sectional study, we investigated the associations between radon hot spring bathing and health conditions. The target population was 5,250 adults ≥ 20 years old in the town of Misasa, Japan. We collected information about the participants’ bathing habits and alleviation of a variety of disease symptoms, and their self-rated health (SRH). Unadjusted and adjusted odds ratios (ORs) and 95% confidence intervals (CI) were calculated. In both the adjusted and unadjusted models of hypertension, significant associations between the > 1×/week hot spring bathing and the alleviation of hypertension symptoms were observed compared to the group whose hot spring bathing was <1×/week: adjusted model, OR 5.40 (95%CI: 1.98-14.74); unadjusted model, 3.67 (1.50-8.99) and for gastroenteritis: adjusted model, 9.18 (1.15-72.96); unadjusted model, 7.62 (1.59-36.49). Compared to the no-bathing group, higher SRH was significantly associated with both bathing < 1×/week: unadjusted model, 2.27 (1.53-3.37) and > 1×/week: adjusted model, 1.91 (1.15-3.19). These findings suggest that bathing in radon hot springs is associated with higher SRH and the alleviation of hypertension and gastroenteritis. |
| キーワード | radon hot spring bathing habit self-rated health cross-section study |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2023-08 |
| 巻 | 77巻 |
| 号 | 4号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 387 |
| 終了ページ | 394 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | Copyright Ⓒ 2023 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 37635139 |
| Web of Science KeyUT | 001163659800003 |
Neuroprotective effects of carnosine in a mice stroke model concerning oxidative stress and inflammatory response
| フルテキストURL | fulltext20230418-05.pdf figure20230418-05.pdf |
|---|---|
| 著者 | Hu, Xinran| f*ckui, Yusuke| Feng, Tian| Bian, Zhihong| Yu, Haibo| Morihara, Ryuta| Hu, Xiao| Bian, Yuting| Sun, Hongming| Takemoto, Mami| Nakano, Yumiko| Yunoki, Taijun| Abe, Koji| Yamash*ta, Toru| |
| キーワード | Ischemic stroke Carnosine Middle cerebral artery occlusion Oxidative stress Inflammation Pyroptosis |
| 備考 | ©2023 Elsevier B.V. This manuscript version is made available under the CC-BY-NC-ND 4.0 License. http://creativecommons.org/licenses/by-nc-nd/4.0/. This is the accepted manuscript version. The formal published version is available at https://doi.org/10.1016/j.jns.2023.120608.| This fulltext file will be available in Apr. 2024.| |
| 発行日 | 2023-04-15 |
| 出版物タイトル | Journal of the Neurological Sciences |
| 巻 | 447巻 |
| 出版者 | Elsevier BV |
| 開始ページ | 120608 |
| ISSN | 0022-510X |
| NCID | AA00703265 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © 2023 Elsevier B.V. |
| 論文のバージョン | author |
| PubMed ID | 36906993 |
| DOI | 10.1016/j.jns.2023.120608 |
| Web of Science KeyUT | 000956027800001 |
| 関連URL | isVersionOf https://doi.org/10.1016/j.jns.2023.120608 |
Radon inhalation decreases DNA damage induced by oxidative stress in mouse organs via the activation of antioxidative functions
| フルテキストURL | fulltext.pdf |
|---|---|
| 著者 | Kataoka, Takahiro| Shuto, Hina| Naoe, Shota| Yano, Junki| Kanzaki, Norie| Sakoda, Akihiro| Tanaka, Hiroshi| Hanamoto, Katsumi| Mitsunobu, Fumihiro| Terato, Hiroaki| Yamaoka, Kiyonori| |
| キーワード | radon oxidative DNA damage Mn-superoxide dismutase (SOD) 8-oxoguanine DNA glycosylase |
| 発行日 | 2021-08-09 |
| 出版物タイトル | Journal of Radiation Research |
| 巻 | 62巻 |
| 号 | 5号 |
| 出版者 | Oxford University Press |
| 開始ページ | 861 |
| 終了ページ | 867 |
| ISSN | 0449-3060 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| OAI-PMH Set | 岡山大学 |
| 著作権者 | © The Author(s) 2021. |
| 論文のバージョン | publisher |
| PubMed ID | 34370027 |
| DOI | 10.1093/jrr/rrab069 |
| Web of Science KeyUT | 000700078300014 |
| 関連URL | isVersionOf https://doi.org/10.1093/jrr/rrab069 |
L-Carnitine Prevents Progression of Non-Alcoholic Steatohepatitis in a Mouse Model with Upregulation of Mitochondrial Pathway
| 著者 | Ishikawa, Hisashi| Takaki, Akinobu| Tsuzaki, Ryuichiro| Yasunaka, Tetsuya| Koike, Kazuko| Shimomura, Yasuyuki| Seki, Hiroyuki| Matsush*ta, Hiroshi| Miyake, Yasuhiro| Ikeda, Fusao| Shiraha, Hidenori| Nouso, Kazuhiro| Yamamoto, Kazuhide| |
|---|---|
| 発行日 | 2014-07-01 |
| 出版物タイトル | PLoS ONE |
| 巻 | 9巻 |
| 号 | 7号 |
| 資料タイプ | 学術雑誌論文 |
Comparison of Urinary Levels of 8-Hydroxy-2’-deoxyguanosine between Young Females with and without Depressive Symptoms during Different Menstrual Phases
| JaLCDOI | 10.18926/AMO/53121 |
|---|---|
| フルテキストURL | 69_1_45.pdf |
| 著者 | Iida, Tadayuki| Inoue, Ken| Ito, Yasuhiro| Ishikawa, Hiroaki| Kagiono, Miwa| Teradaira, Ryoji| Chikamura, Chiho| Harada, Toshihide| Ezoe, Satoko| Yatsuya, Hiroshi| |
| 抄録 | This study aimed to clarify the association between depressive symptoms and a marker of oxidative stress-induced DNA damage in young females. Since the menstrual cycle may confound or modify this association, depressive symptoms and urinary levels of 8-hydroxy-2ʼ deoxyguanosine (8-OHdG) were evaluated during each menstrual phase. A total of 57 female fourth-year students (aged 21.6±0.8) from a Japanese health science university were studied. The menstrual cycle was divided into 3 phases:menstrual (days 1 to 3 after the onset of menses);proliferative (days 13 to 15);and secretory (days 24 to 26). Depressive symptoms were assessed by the self-rating depression scale (SDS). Positive depressive symptoms were defined as a score of 53 or more during 2 different menstrual phases. The association between the presence of depressive symptoms and 8-OHdG levels adjusting for the menstrual cycle was examined by two-way analysis of variance with the menstrual cycle (menstrual, proliferative, and secretory phases) as the within-individual factor. The menstrual cycle did not show a significant correlation with urinary 8-OHdG levels. On the other hand, the menstrual cycle-adjusted 8-OHdG level was significantly higher in those with depressive symptoms (7.01ng/mL) than in those without them (3.98ng/mL). The ROC curve analysis showed that urinary 8-OHdG levels had reasonably high discriminative performance throughout all the menstrual cycles (0.73-0.81;all p＜0.05). These results indicated the presence of oxidative stress in subjects with depressive symptoms independent of the menstrual cycle. |
| キーワード | depression 8-OHdG menstrual cycle |
| Amo Type | Original Article |
| 出版物タイトル | Acta Medica Okayama |
| 発行日 | 2015-02 |
| 巻 | 69巻 |
| 号 | 1号 |
| 出版者 | Okayama University Medical School |
| 開始ページ | 45 |
| 終了ページ | 50 |
| ISSN | 0386-300X |
| NCID | AA00508441 |
| 資料タイプ | 学術雑誌論文 |
| 言語 | 英語 |
| 著作権者 | CopyrightⒸ 2015 by Okayama University Medical School |
| 論文のバージョン | publisher |
| 査読 | 有り |
| PubMed ID | 25703170 |
| Web of Science KeyUT | 000349740300005 |
Comparison of serum ferritin and oxidative stress biomarkers between Japanese workers with and without metabolic syndrome
| 著者 | Iwanaga, Suketaka| Sakano, Noriko| Taketa, Kazuhisa| Takahashi, Noriko| Wang, Da-Hong| Takahashi, Hidekazu| Kubo, Masayuki| Miyatake, Nobuyuki| Ogino, Keiki| |
|---|---|
| 発行日 | 2013-02-01 |
| 出版物タイトル | Obesity Research & Clinical Practice |
| 資料タイプ | 学術雑誌論文 |
Evaluation of urinary hydrogen peroxide as an oxidative stress biomarker in a healthy Japanese population
| 著者 | Sato, Y.| Ogino, K.| Sakano, N.| Wang, D. H.| Yoshida, J.| Akazawa, Y.| Kanbara, S.| Inoue, K.| Kubo, M.| Takahashi, H.| |
|---|---|
| 発行日 | 2013-03 |
| 出版物タイトル | Free Radical Research |
| 巻 | 47巻 |
| 号 | 3号 |
| 資料タイプ | 学術雑誌論文 |
Relationship between ceruloplasmin and oxidative biomarkers including ferritin among healthy Japanese
| 著者 | Inoue, Kiyomi| Sakano, Noriko| Ogino, Keiki| Sato, Yoshie| Wang, Da-Hong| Kubo, Masayuki| Takahashi, Hidekazu| Kanbara, Sakiko| Miyatake, Nobuyuki| |
|---|---|
| 発行日 | 2013-03-01 |
| 出版物タイトル | Journal of Clinical Biochemistry and Nutrition |
| 巻 | 52巻 |
| 号 | 2号 |
| 資料タイプ | 学術雑誌論文 |
Effects of exercise training on gingival oxidative stress in obese rats
| 著者 | Azuma, Tetsuji| Tomofuji, Takaaki| Endo, Yasumasa| Tamaki, Naofumi| Ekuni, Daisuke| Irie, Koichiro| Kasuyama, Kenta| Kato, Tomo| Morita, Manabu| |
|---|---|
| 発行日 | 2011-08 |
| 出版物タイトル | Archives of Oral Biology |
| 巻 | 56巻 |
| 号 | 8号 |
| 資料タイプ | 学術雑誌論文 |
Urinary 8-OHdG elevations in a partial lesion rat model of Parkinson's disease correlate with behavioral symptoms and nigrostriatal dopaminergic depletion
| 著者 | 菊池 陽一郎| |
|---|---|
| 発行日 | 2011-03-25 |
| 出版物タイトル | |
| 資料タイプ | 学位論文 |
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